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Demyelinating lesions,such as those in multiple sclerosis,may resemble primary or metastatic brain tumors on CT or MRI,and even be mistaken for neoplasms on biopsy.We encountered five such patients in whom an incorrect diagnosis of CNS neoplasm was made on the basis of radiologic appearance (five)and biopsy(four).All five received radiation therapy,and three chemotherapy.Review of the pathologic findings indicated that the original lesions were not neoplastic but demyelinative.The four patients who received radiation in full tumoricidal doses had expectedly poor clinical outcome,suggesting that radiation is especially injurious to patients with demyelinating disease. |
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brain biopsy
CAT scan
CAT scan,abnormal
demyelinating disease
gadolinium
headache
misdiagnosis
MRI
MRI,abnormal
MRI,contrast enhanced
MRI,demyelinating disease
multiple sclerosis
multiple sclerosis,misdiagnosis
neoplasm,metastatic to CNS
neoplasm,primary intracerebral
neoplasm,primary of CNS
radiation therapy,CNS treatment and complications with
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